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Last week, at a StrictlyVC event in San Francisco, we sat down with Maryanna Saenko and Steve Jurvetson, investors who came together to create the investment outfit Future Ventures roughly one year ago. It was their first public appearance together since announcing their $200 million fund, and we started by asking Jurvetson about his high-profile split from his old firm DFJ. (He said of the experience that sometimes life forces a dislocation in what youre doing, and it got me to become an entrepreneur for the first time in a long time.)

We also talked about how the two came together and where theyre shopping, as they have fewer constraints than most firms. It was a wide-ranging chat that covered SpaceX and to a lesser extent Tesla, whose boards of directors Jurvetson sits on. We also talked about The Boring Company, in which Future Ventures has a stake, the profound dangers of the AI race between companies (and countries), and whether the powerful psychedelic ayahuasca or something like it might represent an investment opportunity. Included in the mix was what Jurvetson described as potentially the biggest money-making opportunity he has ever seen.

Read on to learn more. Our conversation has been edited lightly for length.

Youve come together to build this new fund that has a 15-year investing horizon. Your interests overlap quite a bit. Maryanna, youre a robotics expert with degrees from Carnegie Mellon; you were with Airbus Ventures before joining DFJ then heading later to Khosla Ventures. Who is better at what?

SJ: Shes better at everything, is the answer, but I think were better as a pair. The beauty of small team is youre better than you would be on your own. I knew when I set off that I didnt want to do it alone. I know that the people Ive worked with over the last 20 years have made me better. The best investments I did at DFJ I largely attribute to the junior partner I was working with at the time, and I might not have done those best deals if I was on my own.

Theres something about the dialectic, the discussion, the debates with someone you respect whose opinion is valuable, so rather than thinking, You handle this, Ill handle that and partitioning it, its more of a [back and forth]. So we have partner meetings all the time, just not any scheduled meetings.

Certainly, Maryannas deep background in robotics is a vein of interest, as is all the aerospace stuff. But just a reminder, when I first interviewed her [Jurvetson originally hired her at DFJ], I was blown away that she had already invested in several of the quirky sectors from quantum computer to phasor antennas for satellites to [inaudible but relating to space].

Of course you would be investing [in this thing Ive never heard of before].

MS: Its going to become relevant, I promise.

Speaking of aerospace, you two have invested in SpaceX, a company that DFJ had also backed. Is this company ever going to go public?

SJ: I think the official last tweet on this matter was that the company will go public after there are regularly scheduled flights to Mars.

Which is when?

SJ: It might not be that far off. Probably within the 15-year [investing] cycle that we have now. Clearly the business is much more dramatic than just that. Thats the big storm on the horizon [that captures a lot of interest] but in the near term, there are multiple billions of dollars in revenue. Theyre a profitable business. And frankly, theyre about to launch what may be the biggest money-making opportunity Ive ever seen in my life, which is the broadband satellite data business [Starlink, which is a constellation being constructed by SpaceX to provide satellite Internet access].

So theres plenty of good stuff happening before we get to Mars. That was just a way to put all the investment bankers off. Theyre continuously hounding the company, When are you going public? When are you going public?

It is 17 years old. Have you made money off it [as an investor] thus far?

SJ: Oh, yeah, at our prior firm, theyve [enjoyed] well over $1 billion in profit [through secondary sales].

What do you think of scientists concerns that these satellites going to ruin astronomy because theyre so bright? I know SpaceX has tried to paint them. I also know SpaceX isnt alone and that Amazon is also trying to put up a constellation, for example. But youre a mission-driven firm. Should we be worried that were littering the sky with these things?

MS: One of the fundamental questions when you invest in technology is what are the second-order effects that were aware of and what are the second-order effects that were not clever enough to foresee ahead of time [and] to look holistically at these problems.

So first and foremost, right, its not just Space X. Many companies these days are trying to put up a constellation whether in [Low Earth Orbit] or [Medium Earth Orbit] or increasingly in [Geostationary Orbit]. We need to think mindfully and work with the scientific communities and say, What are the needs? Because the reality is that the communication is going to go up, and if its not from U.S. companies, itll be from European or from Asian companies. So I think the scientific community needs to wake up, unfortunately, to the reality that the Luddite form of saying, Technology isnt going up to space . . . and they should say say, Heres a set of metrics that wed like to continue moving forward with.

Ideally we can design to those specs. Beyond that, I fundamentally believe well find ways to shine brighter lights and move further [out]. Honestly, most of the interesting imaging happens well past [Low Earth Orbit] and I think when we start building a lunar base, well solve a lot of these problems.

At StrictlyVCs last event, we played host to a supersonic jet company called Boom. There are a handful of companies with which it competes, too

MS: Oh, more than [a handful]. If you count just pure electric aircraft companies, Ive met with 55 of, I would guess, around 200 or 300. Within that, supersonic is smaller, but its still in the dozens.

Whoa, that many? Does the world need supersonic jets again?

MS: [As a] recovering engineer and scientist, the way that I look at the space is does the business model fundamentally [make more sense] than when we tried this the last time in the 80s. If the answer is, This time, were a bunch of clever software kids building an aerospace device and dont worry about it, well figure out how to build an aircraft, Im going to tell you all the reasons that isnt necessarily going to work.

I think on the electric aircraft side, we have a bunch of questions to answer about what is the timeline of battery density versus what is a mission profile for these flights that actually makes sense. On the long-range side, we can look at what SpaceX might do with point-to-point capsules. [At the intermediate stage, hypersonic fight],I have not yet seen an engineering trajectory matched with a business model that I think closes in this space, at all, so Im not sure what the bankers are doing,

SJ: Also, the FAA regulatory cycle is very long. But [in addition to these reasons], our life becomes very simple the moment we know there are 55 to maybe 200 companies in a sector, and this is true for small sat launch or eVTOL aircraft huge swaths of the landscape. Whenever theres more than one or two [companies in a space], we dont even want to meet unless were just trying to understand whats going on. Why would anyone invest in the 130th small sat launch company? We try to look for companies that are unlike anything thats been seen before at the time.

On that note, theres only one new company that I know of thats digging a tunnel-based transportation system, Boring Company. Its another investment of Future Ventures . Did it come with a board seat?

SJ: No. Were in the first round of investment.

Is this a real company? Ive read it takes $1 billion to tunnel through a mile.

SJ: It depends where youre digging. Thats the worst case, but it can be up there, like when Boring Company won this contract in Las Vegas for a very short segment, the competition was bidding like $400 million for just a mile. It was like, really?

If you think about the pattern across aerospace with SpaceX, [the motor] issue with Tesla, and now potentially in construction, fintech, and agriculture, there are industries that havent [seen major innovation] in a long time. So the top four companies in America that are digging tunnels all started in the 1800s. Thats an especially long time ago. And the whole point, too, with Boring is switching diesel to electric, to do continuous digging, to reengineer the entire thing with a software and simulation mindset, to dramatically increase the speed and lower the cost. Think two orders of magnitude cheaper at least.

Steve, youd said once before that in most of the deals youve funded across your career, yours was the only check, that there just wasnt any competition. But more people are focused on the future as an investment theme now. Is it harder to find those outliers?

SJ: Its a little harder. We usually use that as a signal to look to a new market whenever there are multiple checks, When its a category, when there are conferences about it, when other venture firms are talking about it, thats usually a sure-enough sign that we already should have moved on to something else.

MS: The simple reality, too, is the industry is focused on a handful of sectors enterprise software, consumer internet, and the like and often there are fantastic funds with one or two edge-case investments, and thats great, because we love those funds and we want to work with them. But there are very few funds where that trajectory is the straight and narrow of their fundamental thesis.

You raised $200 million for this fund from tech CEOs and hedge funds and VCs; do you have the same constraints that other firms have?

MS: I dont think we have particularly fine constraints on anything, but we do have the constraint of our own conviction, our word and the quality of our characters, so one of the theses when we raised the fund was that we dont prey on human frailty, so no addictive substances, no [social media influencers] and not just because were bad at being cool hunters. But thats not our intention; thats not what were trying to create in the world.

I know youre interested in AI. What does that mean? Are you funding drug development?

SJ: What have you heard? Thats a really good guess.

There are so many companies hundreds of them using AI to try and uncover drug candidates, but they dont seem to be getting very far or maybe theyre arent getting far enough along as fast as Id expected.

SJ: [We have a related deal in process]. Interestingly, weve done ten deals that have closed; we have three more that are in the process, two in the signed term sheet phase. Four are in the area of edge intelligence . . .

MS: Ill often come at things from how would I build this robot in the world to do some critical task and Steve often looks at it more from the chip and power and processing and how you lay the algorithm onto the silicon. And between those two, we arrive at a really interesting thesis up and down the stack. So weve done Mythic, an edge intelligence chip company, but weve also looked at this idea that were going to send out these AIs into the world but we basically bake them into these edge devices that are terrible [because they dont work well].

The real issue is an AI thats getting trained somewhere in some cloud then getting pushed to your edge device and then, good luck. But increasingly [were thinking] about continuous improvement of those AIs as theyre running in real time and mindful of how we shuttle the data back to the mother ship data centers. [Were looking to] enable continuous improvement and acceleration of that learning. We have a number of portfolio companies up and down that stack that Im incredibly excited about.

That all sounds comfortably pedestrian compared to the very big picture, wherein a small group of companies is amassing all the richest data to train AI and are growing more powerful by the day. Steve, youve talked about this before, about your concerns that one day there could be very few companies, which would exacerbate income inequality. You said this could be a bigger threat to society than climate change. Do you think these companies Facebook, Amazon, Google should be broken up?

SJ: No, I dont think they should be broken up, but I do think its an inexorable trend in the the technology business that there are power laws within firms and between firms . . . If you want to maintain capitalism and democracy, its not self-rectifying and its only going to get worse. Compared to when we last spoke about this [in 2015], its gotten a lot worse. The data concentration, the usage of it.

Think, for example, of SenseTime in China . . . it recognizes faces better than any other algorithm on earth right now . . . So you have the U.S. power laws and power laws between countries as well. Thats just one new pejoration as AI and quantum computing escalates.

So everyone in technology and who invests in it should be thoughtful about what this means and think about entrepreneurial paths to the future we want to live in . . . how we get from here to there is not obvious. The markets [will handle some but not all of these things]. So its very worrisome and when I said its worse than climate change, I meant it will have more impact on whether humanity makes it through the next 20 years. Climate change [may do us in] 200 years from now but theres some serious pressing issues over the next 20 years.

And breaking up these companies isnt part of the solution.

Its almost like this notion of controlling an AI thats greater than human intelligence. How would you ever imagine you would control such a thing? How would you even imagine understanding its inner workings? So the notion that through regulation you could break up a natural monopoly when everything that fixes the industry creates a natural monopoly, itd be like whack-a-mole.

Whats the answer? Looking around the corner, what are you funding thats going to blow peoples minds? Ayahuasca? Is there a market for that? I know its everywhere.

SJ: [Looking shocked.] There are two companies, one we wired funds earlier today and the other is a signed term sheet and they relate to your questions.

MS: We should check if the office is bugged [laughs].

SJ: Theres a lot going on. Curing mental illness. Alternative modalities.

MS: The largest rising global epidemic is depression. Adolescent suicide rates are up 300 percent in the U.S. in the last 10 years. And we dont have the resources, the skills, the technologies and the licensed therapists available. We know there are medicinal compounds, often from plant vines, that have shown incredible value in addressing treatment-resistant depressions and addiction and abusive substances. And often participation in those things is a privilege of particular groups in society and so how do we democratize access to mental health.

Wait, I cant believe I guessed it. Youre investing in an ayahuasca-related startup!?

SJ: Its close, not exactly. [Laughs.]

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Maryanna Saenko and Steve Jurvetson of Future Ventures talk SpaceX, the Boring Co. and . . . ayahuasca - TechCrunch