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BOSTON, MA July 14, 2020 New survey results fromthe Pistoia Alliance, the Quantum Economic Development Consortium (QED-C) and QuPharm show almost one-third (31 percent) of life science organizations polled are set to begin quantum computing evaluation this year. A further 39 percent are planning to evaluate next year or have quantum computing on their radar, while 30 percent have no current plans to evaluate.

The three organizations have collaborated to establish a cross-industry Community of Interest (CoI) to explore the opportunities for quantum computing to enhance the efficiency and effectiveness of biopharma R&D. The CoI aims to support companies that need help navigating the pathway to quantum computing and will facilitate collaboration between stakeholders, propose new ideas for quantum computing projects, and help interested parties define and articulate potential use cases.

The interest in quantum computing across many sectors is high, yet most biopharmaceutical companies are only just beginning the journey and exploring the potential for accelerating discovery, commented Emir Roach, one of the leaders of QuPharm. Quantum computing is a completely new paradigm of computing, and our mission is to accelerate its implementation in life sciences. We are looking forward to working with the Pistoia Alliance and QED-C to help educate the life science and health care industry on the benefits.

The survey showed that more than four out of five respondents (82 percent) believe quantum computing will impact the industry within the next decade. The same proportion of respondents believe discovery and development will be first to benefit from quantum computing deployments in the biopharmaceutical industry.

Quantum computing is likely to have a profound impact on precision medicine, enabling accelerated genomics and proteomics correlation, as well as the calculation of multiple probabilities and outcomes. It will also help organizations deliver new molecules and therapies to market faster by streamlining the discovery process and enabling quantum energy calculations for molecules, as predicted in the Pistoia Alliances 2030 vision report. In the future, such technology could help the industry more quickly and accurately model disease pathways caused by novel coronaviruses.

The CoI has come together to help organizations address the key issues that need to be solved if the extraordinary benefits of quantum computing are to be realized. Potential barriers identified in the survey include a shortage of skills and a lack of access to quantum computing infrastructure (both cited by 28 percent of respondents) and the need for clearly defined use cases (31 percent).

There are myriad opportunities for quantum computing in life sciences and health care, and through this community of interest the pharmaceutical and quantum computing sectors can work together to identify and communicate areas of early and high potential, commented Celia Merzbacher, deputy director at QED-C. While quantum computing is still emerging, now is the time to jointly define use cases and challenges in pharmaceutical discovery and development that quantum computing can address. Better understanding of the pharmaceutical bottlenecks can accelerate quantum computing hardware and software development for overcoming those.

Given the interest in quantum computing amongst our members, we wanted to create the community of interest to address their needs and questions. We are now looking for more companies to get involved and commit resources to help us explore use cases, commented John Wise, a member of the Pistoia Alliance Operations Team supporting the new quantum computing CoI. The shared-risk, shared-reward advantages of pre-competitive collaboration are an ideal way for companies to explore the opportunities and challenges of quantum computing. Those organisations that do not begin to evaluate quantum computing now are at risk of being left behind once its value is realized. Those that are equipped to adopt the technology when it matures will be significantly ahead.

The research survey was conducted at the Community of Interests inaugural webinar in June 2020. More than 240 attendees from life science and quantum computing organisations across the US and Europe participated. To find out more about the CoI and help to steer future projects on quantum computing, please contact John Wise at the Pistoia Alliance via john.wise@pistoiaalliance.org or Celia Merzbacher via celia.merzbacher@sri.com.

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Almost One-Third of Life Science Companies Set to Begin Quantum Computing Evaluation This Year - Lab Manager Magazine

Three of our gang, you see, were women. On our second morning, all three found their periods had kicked in. They were so charmed and amused by this that they forgot any possible cramps or migraines. This was, they told us ignorant men, menstrual synchrony" the tendency for women who live together to begin menstruating on the same day every month. In 1971, a psychologist called Martha McClintock studied 180 women in a college dormitory. Menstrual synchrony, she concluded then, was real.

Now, this really didnt apply that weekend in NYC, because these ladies had only spent one day together. Besides, more recent research has questioned McClintocks findings. Even so, those long-ago NYC days came back to me after reading about some even more recent research, at IIT Kanpur. Not about menstruation, but about synchronization, and in the quantum world.

Whats synchronization? Imagine an individual a bird, a pendulum doing a particular motion over and over again. The bird is flapping its wings as it flies, the pendulum is swinging back and forth. Imagine several such individuals near each other, all doing the same motion several birds flying together in a flock, several pendulums swinging while hanging from a beam. When they start out, the birds are flapping to their own individual rhythms, the pendulums going in different directions. But then something beautiful happens: these individual motions synchronize. The birds flap in perfect coordination, so the flock moves as one marvellous whole. The pendulums swing in harmony.

In fact, synchronization was first observed in pendulums. In 1665, the great Dutch scientist Christiaan Huygens attached two pendulum clocks to a heavy beam. Soon after, the two pendulums were in lockstep.

Similarly, fireflies are known to break into spontaneous synchrony. When there are just one or a few, they light up at different timesa pleasant enough sight, but nothing to write home about. But there are spots in the coastal mangroves of Malaysia and Indonesia where whole hosts of the little insects congregate every evening and suddenly, synchrony happens. They switch on and off in perfect unison, putting on a light show like none youve seen.

There are, yes, other examples. At a concert, the audience will tend to applaud in sync. The reason we only ever see one side of the Moon is that the orbital and rotational periods of the Moon have, over time, synchronized with the rotation of our Earth. Your heart beats because the thousands of pacemaker" cells it contains pulse in synchrony. Some years ago, a bridge of a new and radical design was built over the Thames in London. When it was opened, people swarmed onto it on foot. It quickly started swaying disconcertingly from side to side enough, in turn, to force the pedestrians to walk in a certain awkward way just to keep their footing. On video, youll see hundreds of people on the bridge, all walking awkwardly but in step.

In his book Sync: The Emerging Science of Spontaneous Order, the mathematician Steven Strogatz writes: At the heart of the universe is a steady, insistent beat: the sound of cycles in sync. It pervades nature at every scale from the nucleus to the cosmos." He goes on to observe that this tendency for synchronization does not depend on intelligence, or life, or natural selection. It springs from the deepest source of all: the laws of physics". And thats where IIT Kanpur comes in.

In 2018, a team of Swiss researchers looked at the possibility of synchronization at the lower end of that scale that Strogatz mentions, or in some ways even off that end of the scale. Do the most elementary, fundamental particles known to physicists exhibit the same tendency to synchronize as somewhat larger objects such as starlings and pendulums and the moon? Were talking about electrons and neutrons, particles that occupy the so-called quantum" world. Can we get them to synchronize?

They concluded that the smallest quantum particles actually cannot be synchronized. These exhibit a spin"a form of angular momentum, in a sense the degree to which the particle is rotating of 1/2 (half). But there are ways in which such spin-half" particles can combine to form a spin-1" system, and the Swiss team predicted that these combinations are the smallest quantum systems that can be synchronized.

So, a physics research group at IIT Kanpur decided to test this prediction. These are guys, I should tell you, who are thoroughly accustomed to working with atoms: One day in 2016, their professor, Dr Saikat Ghosh, took me into their darkened lab and pointed to a small red glow visible in the middle of their apparatus. Thats a group of atoms," he said with a grin, and then tweaked some settings and the glow dropped out of sight. The point? They are able to manipulate atoms. On another visit, they underlined this particular skill by showing me their work with graphene, a sheet of carbon that is get this one atom thick.

So, after the Swiss prediction, Ghosh and his students took a million atoms of rubidiuma soft, silvery metal and cooled them nearly to whats known as absolute zero", or -273 Celsius. Could they get these atoms to show synchrony?

Lets be clear about what they were dealing with, though. The usual objects that synchronize pendulums, birds are called oscillators" because they are in some regular, rhythmic motion. Strictly, it is that motion of the oscillators that synchronizes. But were dealing here with objects we can see, which means the rules of classical" physics apply. Quantum objects like atoms behave differently. In fact, Ghosh told me that spin-1 atoms are not really oscillating in the same sense as pendulums and starlings in flight. Still, with that caveat in place, there are ways in which we can abstract their motion and treat them as oscillators.

In their experiment, the IIT team shot pulses of light at the group of rubidium atoms. Light is made up of photons, which are like minuscule bundles of energy. When they hit an atom, they flip" its spin. Embodied in that flip is the photons quantum information; in a real way, the photons are actually stored in these flipped atoms. This happens with such precision that you can later flip the atoms back and release the photons, thus retrieving" the stored light. In fact, with this storage and retrieval behaviour, the atoms are like memory cells, and this is part of the mechanism of quantum computing. (See my column from October 2018, Catch a quantum computer and pin it down).

But when the atoms are flipped and they store these photons, something else happens to them. When the light is retrieved, the IIT team found it displays interference fringes" a characteristic pattern of light and shadow (similar in concept to what causes stripes on tigers and zebras, or patterns in the sand on a beach). From this fringe pattern, the scientists can reconstruct the quantum state the atoms were inand voil, theres synchrony.

Did each individual atom synchronize to the light and since all one million atoms did so, is that how they are synchronized with each other as well? Thats to be tested still, but its a good way to think of what happened. Again, take fireflies. In one experiment, a single flashing LED bulb was placed in a forest. When the fireflies appeared, they quickly synchronized to the flashing bulb, and therefore to each other. As Dr Ghosh commented: two fireflies synchronizing is interesting, but an entire forest filled with fireflies lighting up in sync reveals new emergent patterns."

There are implications in all this for, among other things, quantum computing. The IIT teams paper remarks; [The] synchronization of spin-1 systems can provide insights in open quantum systems and find applications in synchronized quantum networks." (Observation of quantum phase synchronization in spin-1 atoms, by Arif Warsi Laskar, Pratik Adhikary, Suprodip Mondal, Parag Katiyar, Sai Vinjanampathy and Saikat Ghosh, published 3 June 2020).

There will be other applications too. But over 350 years after Christiaan Huygens stumbled on classical" synchronization, the IIT team has shown for the first time that this strangely satisfying behaviour happens in the quantum world too. No wonder their paper was chosen recently for special mention in the premier physics journal, Physical Review Letters.

A round of applause for the IIT folks, please. I know it will happen in synchrony.

Once a computer scientist, Dilip DSouza now lives in Mumbai and writes for his dinners. His Twitter handle is @DeathEndsFun

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Opinion |Dance of the synchronized quantum particles - Livemint