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Bitcoin Now Costs $12,500 at This Trust, And You Can Even Buy It – U.Today

Arman Shirinyan

Exposure to Bitcoin can be far cheaper when using this fund, but there are some downsides

The Grayscale Bitcoin Fund was one of the main ways to receiveexposure to the cryptocurrency market for the majority of institutional investors back in the 2017 bullrun era. However, with the appearance of Bitcoin futures ETPs, the attention of investors shifted and the discount of the fund started rising to unprecedented values.

According to data shared by Arcane Analytics, it is farcheaper to getexposure to BTC via Grayscale compared to the spot. The discount against the NAV of the GBTC fund reached the record of 36%, making it farmore profitable to buyBitcoin via the fund rather than using the spot asset.

The current discount onGBTC and the lack of inflows into it paint a clear picture: institutional investors do not feel like it is a good time for investing in Bitcoin and the cryptocurrency market in general.

A high discount against NAV might turn out to be a good opportunity for investors when Bitcoin enters the uptrend once againsince the discount tends to turn premium when the demand for suchexposure is on the rise.

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Unfortunately, some investors prefer avoiding GBTC, considering some downsides like the minimum investment value of $50,000, which does not apply to secondary markets, a lock period and a noteworthy management fee.

Generally, institutional inflows to the cryptocurrency market are going through tough times, considering the almost nonexistent volume on Bitcoin and Ethereum ETPs and funds in both the U.S. and Canada.

The crisis on the institutional side of the market will most likely continue until the U.S. pushes a strict monetary policy to battle inflation.

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Yale increases investment in blockchain research – Yale Daily News

Yale, which was ranked 34 in Coindesks 2022 Best Universities for Blockchain, has invested significantly in the rapidly growing field.

Alex Ye 12:08 am, Oct 12, 2022

Staff Reporter

Zoe Berg, Senior Photographer

This time last year, Yale was unranked in CoinDesks Best Universities for Blockchain. A year later the University places 34th overall, on par with Harvard and other major universities around the world.

The reports results recognize Yales recent significant investments into blockchain research, including the hiring of four new blockchain experts to the Computer Science faculty, Ben Fisch, Charalampos Papamanthou, Katerina Sotiraki and Fan Zhang one of whom is leading a project that has received a $5.75 million grant for blockchain development.

In the last few years, blockchain, as an interdisciplinary field, has spurred a huge amount of development in distributed systems and cryptography and their intersection, said Fisch. This is also why its such a fascinating academic topic, because it ties together so many different fields, not only from computer science, but also from economics, law and policy. Yale has a very unique combination of strengths in all these different areas, especially at present.

In August, Yale blockchain researchers accepted a $5.75 million grant from the Algorand Foundation, a not-for-profit organization focused on the development of blockchain technology.

The grant will support PAVE: A Center for Privacy, Accountability, Verification and Economics of Blockchain Systems, which will be led by Papamanthou. PAVE will bring together a cross-disciplinary team of experts from four institutions Yale, Columbia University, the City College of New York and the Swiss Federal Institute of Technology Lausanne, with Yale being the leading institution to advance research of blockchain systems.

Apart from the technical agenda, PAVE will also host hackathons, symposiums and blockchain summer schools.

The expansion of blockchain research at Yale coincides with the rise of the blockchain technology market. The value of blockchain technology in the banking, financial services and insurance sector market is expected to grow by $4.02 billion between 2021 and 2026, according to Technavio. The Technavio study found that easier access to technology and disintermediation of banking services will create more growth opportunities within the industry.

Papamanthou believes the hirings acknowledged the importance of blockchain, and that the University has more generally acknowledged the interdisciplinary nature of the blockchain space. He emphasized the University provides opportunities to explore the blockchain industry, such as interdisciplinary majors like computer science and economics.

Papamanthou spotlighted the newly established Roberts Innovation Fund created by the School of Engineering and Applied Sciences, which assists blockchain projects that could be commercialized through funding and mentoring.

An increasing number of students are interested in the field of blockchain, according to Mariam Alaverdian 23, president of the Yale Blockchain Club.

Alaverdian explained that because of the many applications of blockchain technology from personal identity security to healthcare to money transfers the emergence of blockchain into our lives is inevitable. She added that the Yale Blockchain Club has seen interested students come from a variety of backgrounds, with some having no prior exposure and others who already have startups in the space.

The Yale Blockchain Club started last spring and we received a lot of attention from Yale undergraduate and graduate students, Alaverdian wrote in an email to the News. We had 600 people sign up for our mailing list within a couple of weeks there is definitely a high demand from Yale students for educational materials and guidance.

As the blockchain industry has continued to grow, Yale has been a fierce advocate for blockchain research and development, Papamanthou noted.

Papamanthou explained that because Yales faculty is now made up of leaders in the field of

distributed computing and cryptography, the potential blockchain innovation at Yale could be unprecedented.

Its amazing that Yale has hired two phenomenal professors, Ben Fisch and Fan Zhang, whose research focuses on aspects of blockchains, said Roshan Palakkal 25, a student in Frontiers of Blockchain Research, a course taught by Fisch. Yale CS typically isnt known to be the best, but I think the new classes and faculty have positioned it to become one of the best universities for blockchain, with lots of potential for interdisciplinary collaboration in areas like economics, global affairs, and public policy.

Papamanthou added that students who are interested in blockchain have access to a variety of courses across the Computer Science and Economics Departments, as well as at the Yale School of Management and Yale Law School.

According to Fisch, from a computer science perspective, Yale is educationally competitive with any other university in the field of blockchain.

I will be offering a course in the spring that is comparable to the blockchain course thats offered by Stanford, Fisch said. And the research seminar that Im teaching now is uncommon at other universities, as it really goes in depth at a graduate level into all the most recent research topics that are being worked on currently.

The Yale Computer Science Department is located at 51 Prospect St.

Alex Ye covers faculty and academics. He previously covered the endowment, finance and donations. Originally from Cincinnati, Ohio, he is a sophomore in Timothy Dwight majoring in applied mathematics.

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RIT faculty prepare to teach large classes in SHED using scaled-up classroom | College of Science | RIT – Rochester Institute of Technology

Students in an 8 a.m. principles of data management class talk among each other as they solve a data base problem. Sometimes they get up and write on a 6-foot whiteboard on wheels that doubles as a screen between tables of students in their extra-large classroom.

The room in Slaughter Hall seats 150 students and is meant to simulate the learning spaces in the Student Hall for Exploration and Development (SHED) that will hold classes next fall. The Slaughter classroom, dubbed the betaSHED, combines three rooms to give professors and students a preview of the large-scale learning environment.

Emanuel Griffin, a third-year computer science major from Brooklyn, N.Y., said its hard to learn when a professor stands in front of the room and lectures or reads from their Power Point slides.

Here its really different because you take the material and then use it on the problem, Griffin said. You also collaborate with classmates and get feedback and learn how to do it properly. I like it a lot.

Instead of lecture-hall seating, the students sit at tables of six and function as their own cohort. Professors and teaching assistants circle through the classroom answering questions.

You can feel how many people are here, but its also large enough that you dont feel cramped, said Jackson Connor, a third-year computer science major from Lancaster, N.Y. Its a nice change of pace from other classes.

The betaSHED classroom combines three sections of the same computer science class. Next fall, five large format, active-learning classrooms in the SHED will combine some multi-section classes and seat up to 150 students. Projectors, screens, and other learning technologies will enhance these spaces.

Jeremy Brown 01 (computer science) and Scott Johnson 14 (computer science) 14 MS (computer science), senior lecturers in the Department of Computer Science, co-teach the principles of data management class in the practice SHED classroom. They had long wanted to flip their classroomsputting lectures on videos and focusing on activities and group work during classtime. It wasnt until the COVID pandemic forced educators to rethink how they deliver information that Brown and Johnson created their video lectures and began creating a library of activities.

The activities are tricky to create. They must challenge students without discouraging them and fill the class time. We have spent many semesters rewriting and revamping activities that ask students to do more than look up answers in a textbook, Brown said.

Active learning means a lot of different things, Johnson said. For us, it's more about engaging the students with each other. Instead of the students just sitting in lecture, being bored and taking notes, they are now doing lecture outside of class and then coming in and consulting with their peers, he said. They teach each other.

This style of teaching can reduce failure rates, improve grades and attendance, create community among students, and allow for more professor-student interaction. It is also inclusive. Deaf and hard-of-hearing students in these cohorts face their peers and the sign language interpreter sits at the table with them, Johnson said.

The dynamic in Johnson and Browns data management class creates an upbeat vibe in the room.

I can see what the positive impacts are with everyone in the same space and having more people together, and the collaborative energy, said Uzo Ukekwe, a third-year computer science major, from Monroe, N.Y.

Key to active learningespecially in large format classesis the prep work that takes place ahead of time. For Michelle Weatherell 04 (biology) 12 MS (environmental science), lecturer in the Thomas H. Gosnell School of Life Sciences, this means working with the general biology lecture instructor team, which includes Sandi Connelly and Emily Coon-Frisch, to plan activities and problem-solve the logistics of preparing and transporting materials needed for their large sections of general biology. This semester, Weatherell, who teaches in the betaSHED room, uses two teaching assistants to enhance learning in the large classroom.

The students, in my opinion, seem to be more confident and comfortable with the material, Weatherell said. I also feel that more students are asking questions above the material, and applying it outside of what we are doing.

Weatherell encourages faculty who are curious about active learning to observe one of the classes in the large room.

It's interesting to see how instructors are using this space because everyone interprets active learning a little bit differently, Weatherell said.

Brown and Johnson have already booked classtime in the betaSHED room for the spring semester and are eager to teach in the SHED when it opens in fall 2023. They have seen the benefits of active learning and apply elements of it in every class they teach. Students with different learning styles appreciate the difference.

Nate Mount, a second-year computer science major from Westminster, Md., said the small group projects keep him focused. Here the professors are able to move around and check you along with the TAs and it keeps you more in the mindset of the material youre looking into that day.

Courses that lend themselves to active learning can help students get the most out of a class, Brown observed.

Students are changing, Brown said. They arent used to being lectured to for hours on end. Active learning is about getting them engaged.

Workshops for active learning

Workshops for RIT faculty, adjunct faculty, and teaching assistants will share strategies for adopting active learning in regular-sized classes and for the extra-large learning spaces that will be available next fall in the Student Hall for Exploration and Development. National expert Andy Gerhart, professor of mechanical, robotics, and industrial engineering at Lawrence Technological University and facilitator for KEEN (the Kern Entrepreneurial Engineering Network), will share his best practices for facilitating learning through small group collaborations. Registration is required to attend the free, in-person workshops:

The Center for Teaching and Learning is sponsoring the workshops, following a remote session Gerhart led via Zoom in September. Contact Sandi Connelly, interim associate director, at sjcsbi@rit.edu to view the recording of the earlier session.

To learn more about teaching in the SHED, go to TeachSHED.

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Amazon Fellows and faculty-led projects advance innovations in machine learning and artificial intelligence – Virginia Tech Daily

TheAmazonVirginia Tech Initiative for Efficient and Robust Machine Learninghas announced support for two Amazon Fellows and four innovative research projects led by Virginia Tech faculty that further the initiatives mission of advancing new directions in machine learning.

Funded by Amazon, housed in theCollege of Engineering,and directed by researchers at theSanghani Centerfor Artificial Intelligence and Data Analyticson Virginia Techs campus in Blacksburg and at the Innovation Campus in Alexandria, the initiative was launched in March to support student and faculty-led development and implementation of innovative approaches to robust machine learning such as ensuringthat algorithms and models are resistant to errors and adversaries that could address worldwide industry-focused problems.

An open call for student fellowship nominations and research projects went out concurrently across the Virginia Tech campuses. The initiatives advisory committee, comprised of Virginia Tech faculty and Amazon researchers, selected two Amazon Fellows from among 11 nominations and four faculty award recipients from 14 submissions.

Our inaugural cohort of fellows and faculty-led projects showcases the breadth of machine learning research happening at Virginia Tech, saidNaren Ramakrishnan, the Thomas L. Phillips Professor of Engineering and director of the Amazon-Virginia Tech Initiative. The areas represented include federated learning, meta-learning, leakage from machine learning models, and conversational interfaces.

This research will not only contribute to new algorithmic advances, but also study issues pertaining to practical and safe deployment of machine learning, said Ramakrishnan who also directs theSanghani Centerfor Artificial Intelligence and Data Analytics. We are very excited that the partnership between Amazon and Virginia Tech has enabled these projects.

"The talent and depth of scientific knowledge at Virginia Tech is reflected in the high-quality research proposals and Ph.D. student fellowship applications we have received, said Prem Natarajan, vice president of Alexa AI. I am excited about the new insights and advances in robust machine learning that will result from the work of the faculty and students who are contributing to this initiative."

The Amazon Fellows are:

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Governor Hutchinson Selected to Lead National Education Organization – Governor Asa Hutchinson

Go Back For Immediate Release 10.11.2022 Governor Hutchinson Selected to Lead National Education Organization

LITTLE ROCK Governor Asa Hutchinson has been selected as Chairman of the Education Commission of the States (ECS),a national, nonpartisan organization that serves as a partner to state education leaders.

"It is an honor to have been selected as Chairman of ECS," Governor Hutchinson said. "Arkansas has been a leader in education from computer science to pandemic learning, and I am excited for the opportunity to work with other leaders to secure our children's future."

During his time as Chairman, Governor Hutchinson will lead the Chair's Initiative, which will focus on expanded computer science education.

The Governor's selection comes on the heels of his recent tenure as National Governors Association Chairman, where he led the most successful Chair's Initiative in the organization's history. The Compact to ExpandK-12 Computer Science Education was signed by 50 state and territorial governors, the most ever for a Chairman's Initiative.

ECS' team of experts provides trusted information and opportunities for partnership that allow policymakers to gain the insight and experience needed to create effective education policy for their states.

You can find more information on the Education Commission of the StatesHERE.

CONTACT:Press Shop (press@governor.arkansas.gov)

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Computer science at University of Waterloo ranked number one nationally for third year in a row – CTV News Kitchener

The Cheriton School of Computer Science at the University of Waterloo (UW) has been ranked number one nationally for a third year in a row, according to Macleans 2023 university rankings released this week.

Based on program and research reputation, computer science at UW shared the podium for first place with the computer science programs at the University British Columbia and University of Toronto.

Its gratifying to see that the Cheriton School of Computer Science is in the top spot nationally for both program and research reputation once again, said Raouf Boutaba, professor and director of the Cheriton School of Computer Science in a media release. We are fortunate to have a virtuous circle of talent, where our exceptional undergraduate and graduate students help us attract excellent faculty and staff, who in turn attract top students.

This years Macleans 32nd annual university rankings continued a mandate established in 1991 to provide essential information to help students choose the university that best suits their needs and career aspirations.

The results of the Macleans 2023 rankings were released on Oct. 6.

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Insects Get ‘Caught on Camera’ to Help Farmers in Latest Short Takes – University of Arkansas Newswire

Photo by Russell Cothren

Khoa Luu and Ashley Dowling monitor insect activity at the U of A Farm.

The U of A and U of A System Division of Agriculture researchers have developed a prototype of an insect trap that can help farmers monitor and identify potential pests more efficiently.

Ashley Dowling, a professor of entomology and plant pathology conducting research for the Arkansas Agricultural Experiment Station, partnered with Khoa Luu, an assistant professor of computer science and computer engineering, to create a trap that captures footage of insects, uses artificial intelligence to identify them and sends real-time data back to the farmers.

Once farmers become aware that certain pests are present, they can take the appropriate measures to counteract their potential damage.

The trap itself was created by a local Arkansas business [SolaRid AR], and they came to the university with lots of ideas about what theyd like their trap to be able to do, Dowling said. One of the things on their list was this smart trap approach to things. We jumped at the chance to work with them and create this for them.

Prior to the development of this prototype, farmers typically set traps manually and then sent someone out to evaluate them every few days a process that takes much longer and can sometimes result in crops being ruined in the meantime.

Oftentimes, by the time they get the data, its almost too late, Dowling says.

The new device, however, eliminates the need for manual monitoring, so farmers can make decisions on the fly.

The trap itself is attracting insects using lights of certain wavelengths that are attractive to insects, Dowling explains. It also has the ability to put chemical odors into it that you can target very specific insects with.

As insects beeline their way into the trap, they pass through a sensor with an infrared plane, which then activates the camera. From here, the computer uses artificial intelligence perfected by Luu to identify the insect and transmit the results to the user.

Dowling explains that when certain thresholds of insects are reached in a field, that tells the farmer its time to take action, particularly to avoid substantial economic losses. And, knowing if the pests are isolated to a certain area allows farmers to target only the areas that are potentially affected.

Beyond the fields, the technology has the capability of being applied in other areas of entomology, like biodiversity or museum collections, where samples containing thousands of specimens are regularly collected and need to be analyzed in a timely manner.

Learn more about Dowling and Luus smart insect monitoring system inCaught on Camera: Insects Editionand find additionalShort Takesvideos here.

About the University of Arkansas:As Arkansas' flagship institution, theUofAprovides an internationally competitive education in more than 200 academic programs. Founded in 1871, theUofAcontributes more than$2.2 billion to Arkansas economythrough the teaching of new knowledge and skills, entrepreneurship and job development, discovery through research and creative activity while also providing training for professional disciplines. The Carnegie Foundation classifies theUofAamong the few U.S. colleges and universities with the highest level of research activity.U.S. News & World Reportranks theUofAamong the top public universities in the nation. See how theUofAworks to build a better world atArkansas Research News.

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Ridgefield teen one of 369 students in the world to achieve perfect score on college level test – The Ridgefield Press

RIDGEFIELD A local high school senior's plans to study computer science in college are off to a strong start after he achieved a perfect score on the Computer Science Advanced Placement (AP) test.

Ryan Williams, 17, a Ridgefield High School senior, was one of 369 students in the world to get a perfect score on the test.

Out of 77,434 students worldwide that took the exam, 369 students less than .5 percent earned a perfect score, said Steven Anton, a math, computer science and engineering teacher at Ridgefield High School.

A lot of the Computer Science AP test, Ryan said, is about coding. A multiple choice question might ask students to look at a section of code and identify what it does, while a free response question might ask students to handwrite code to complete a task, like organizing a group of animals in alphabetical order.

You can study for it, Ryan said of the test. You can study for the material theres 10 units in the computer science curriculum, but theres also an aptitude part of the test. Generally, I find the people that enjoy class end up doing better on the exam just because a lot of computer science is application based. The more projects you do in the class and the more interested you are in the projects, the more youll get out of it.

Ryan said he took the Computer Science AP test in early May and found out about his perfect score a few weeks ago. In terms of what constitutes a perfect score, Ryan said he got every point on the exam correct.

Anton said Ryan received a score of 5 on the AP exam, which is scored on a 1-to-5 scale. However, he said a 5 encompasses a range of scores since the test has 80 possible points to earn. As an example, Anton said a 5 might be earned by any score between 62 and 80. Ryans perfect score, Anton said, means Ryan earned all the points possible and that he scored 80/80.

Its so exciting, especially because I want to go into computer science and software, Ryan said. I love the course, I love the teachers as well and it feels kind of surreal to do something like this as well as making my teacher and school and community proud as well.

Having studied computer science with him for two years, Ryan accredited Anton as a mentor that helped nurture his interest in computer science.

As a teacher in general, he makes you feel comfortable in the classroom, Ryan said of Anton. Hes always willing to take questions, he jokes around with the students. That makes it a nice and joyful learning environment rather than a strict one, but at the same time, hes also very good at teaching the course and provides the necessary assessments and encourages students to do their best. Hes been a mentor and kind of grown my interest and love for this.

Ryan was is the student that you know was always excited to learn more about computer science, Anton said of Ryan. You could tell he was very passionate about the subject and interested in learning more, and he kind of just always dove into the projects and was excited to learn more and understand the material hes covering.

I am extremely proud of Ryan for his hard work, Anton said. He worked hard through both of my classes and I think that the perfect score really reflects that its hard work but its also really meticulous effort on the exam where you really have to pay attention and focus. Theres a lot of little things that could go wrong and to score absolutely perfectly is incredible.

After graduating high school, Ryan plans to get his Bachelors degree in college and study computer science and software engineering. While hes not sure where hell attend school next fall, he's a dual citizen of the United States and Canada and has applied to different schools in both countries, including Stanford University in Stanford, Calif.; MIT in Cambridge, Mass.; the University of Toronto in Toronto, Ontario; McGill University in Montreal, Quebec; and the University of Waterloo in Waterloo, Ontario.

Taking Ryans plans to study software engineering into account, Anton said the perfect score itself might not have any direct impact in terms of college, unless schools consider it while looking at admission.

The score of 5 will be accepted by some schools for college credit but that is the same with any score of 5 on the exam, even if it is not a perfect score, Anton said. There could be other impacts that I am not aware of, however. Ryan is my first student to earn a perfect score in the years I've taught the AP course so I am unsure of the full impact.

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MIT system sees the inner structure of the body during physical rehab – MIT News

A growing number of people are living with conditions that could benefit from physical rehabilitation but there arent enough physical therapists (PTs) to go around. The growing need for PTs is racing alongside population growth, and aging, as well as higher rates of severe ailments, are contributing to the problem.

An upsurge in sensor-based techniques, such as on-body motion sensors, has provided some autonomy and precision for patients who could benefit from robotic systems to supplement human therapists. Still, the minimalist watches and rings that are currently available largely rely on motion data, which lack more holistic data a physical therapist pieces together, including muscle engagement and tension, in addition to movement.

This muscle-motion language barrier recently prompted the creation of an unsupervised physical rehabilitation system, MuscleRehab, by researchers from MITs Computer Science and Artificial Intelligence Laboratory (CSAIL) and Massachusetts General Hospital. There are three ingredients: motion tracking that captures motion activity, an imaging technique called electrical impedance tomography (EIT) that measures what the muscles are up to, and a virtual reality (VR) headset and tracking suit that lets a patient watch themselves perform alongside a physical therapist.

Patients put on the sleek ninja-esque all-black tracking suit and then perform various exercises such as lunges, knee bends, dead lifts, leg raises, knee extensions, squats, fire hydrants, and bridges that measure activity of quadriceps, sartorius, hamstrings, and abductors.VR captures 3D movement data.

In the virtual environment, patients are given two conditions. In both cases, their avatar performs alongside a physical therapist. In the first situation, just the motion tracking data is overlaid onto their patient avatar. In the second situation, the patient puts on the EIT sensing straps, and then they have all the information of the motion and muscle engagement.

With these two conditions, the team compared the exercise accuracy and handed the results to a professional therapist, who explained which muscle groups were supposed to be engaged during each of the exercises. By visualizing both muscle engagement and motion data during these unsupervised exercises instead of just motion alone, the overall accuracy of exercises improved by 15 percent.

The team then did a cross-comparison of how much time during the exercises the correct muscle group got triggered between the two conditions. In the condition where they show the muscle engagement data in real-time, that's the feedback. By monitoring and recording the most engagement data, the PTs reported a much better understanding of the quality of the patient's exercise, and that it helped to better evaluate their current regime and exercise based on those stats.

We wanted our sensing scenario to not be limited to a clinical setting, to better enable data-driven unsupervised rehabilitation for athletes in injury recovery, patients currently in physical therapy, or those with physical limiting ailments, to ultimately see if we can assist with not only recovery, but perhaps prevention, says Junyi Zhu, MIT PhD student in electrical engineering and computer science, CSAIL affiliate, and lead author on a new paper about MuscleRehab. By actively measuring deep muscle engagement, we can observe if the data is abnormal compared to a patient's baseline, to provide insight into the potential muscle trajectory.

Current sensing technologies focus mostly on tracking behaviors and heart rates, but Zhu was interested in finding a better way than electromyography (EMG) to sense the engagement (blood flow, stretching, contracting) of different layers of the muscles. EMG only captures muscle activity right beneath the skin, unless its done invasively.

Zhu has been digging into the realm of personal health-sensing devices for some time now. Hed been inspired by using EIT, which measures electrical conductivity of muscles, for his project in 2021 that used the noninvasive imaging technique to create a toolkit for designing and fabricating health and motion sensing devices. To his knowledge, EIT, which is usually used for monitoring lung function, detecting chest tumors, and diagnosing pulmonary embolism, hadnt been done before.

With MuscleRehab, the EIT sensing board serves as the brains behind the system. Its accompanied by two straps filled with electrodes that are slipped onto a users upper thigh to capture 3D volumetric data. The motion capturing process uses 39 markers and a number of cameras that sense very high frame rates per second. The EIT sensing data shows actively triggered muscles highlighted on the display, and a given muscle becomes darker with more engagement.

Currently, MuscleRehab focuses on the upper thigh and the major muscle groups inside, but down the line theyd like to expand to the glutes. The team is also exploring potential avenues in using EIT in radiotherapy in collaboration with Piotr Zygmanski, medical physicist at the Brigham and Womens Hospital and Dana-Farber Cancer Institute and Associate Professor of Radiation at Harvard Medical School.

We are exploring utilization of electrical fields and currents for detection of radiation as well as for imaging of the of dielectric properties of patient anatomy during radiotherapy treatment, or as a result of the treatment, says Zygmanski. Radiation induces currents inside tissues and cells and other media for instance, detectors in addition to making direct damage at the molecular level (DNA damage). We have found the EIT instrumentation developed by the MIT team to be particularly suitable for exploring such novel applications of EIT in radiotherapy. We are hoping that with the customization of the electronic parameters of the EIT system we can achieve these goals.

This work advances EIT, a sensing approach conventionally used in clinical settings, with an ingenious and unique combination with virtual reality, says Yang Zhang, assistant professor in electrical and computer engineering at the UCLA Samueli School of Engineering, who was not involved in the paper. The enabled application that facilitates rehabilitation potentially has a wide impact across society to help patients conduct physical rehabilitation safely and effectively at home. Such tools to eliminate the need for clinical resources and personnel have long been needed for the lack of workforce in healthcare.

The papers MIT co-authors are graduate students Yuxuan Lei and Gila Schein, MIT undergraduate student Aashini Shah, and MIT Professor Stefanie Mueller, all CSAIL affiliates. Other authors are Hamid Ghaednia, instructor at the Department of Orthopaedic Surgery of Harvard Medical School and co-director of Center for Physical Artificial Intelligence at Mass General Hospital; Joseph Schwab, chief of the Orthopaedic Spine Center, director of spine oncology, co-director of the Stephan L. Harris Chordoma Center, and associate professor of orthopedic surgery at Harvard Medical School; as well as Casper Harteveld, associate dean and professor at Northeastern University. They will present the paper at The ACM Symposium on User Interface Software and Technology later this month.

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Most preprint studies of COVID-19 hold up through peer-review – University of Wisconsin-Madison

Research findings posted online as preprints studies made public before undergoing the review and approval of a panel of peer scientists required by most scholarly journals often hold up quite well to that scrutiny, according to a new report on COVID-19 studies.

While preprint manuscripts have become popular in many scientific fields since physicists made their arXiv (pronounced archive) repository accessible online in 1991, the COVID pandemic pushed new groups of researchers into the habit of posting and consulting fresh experimental results and analyses ahead of peer review.

Preprints have been broadly accepted in the social sciences, computer sciences, mathematics for quite a long time, says B. Ian Hutchins, a professor in the University of WisconsinMadisons Information School and leader of the new study of preprint published today in The Lancet Global Health. Biomedical research has been more cautious, I think, precisely because people use that information for making health-altering decisions.

The appearance and speedy global spread of a new virus as well as the quick response by scientists around the world forced many to reconsider that caution, weighing it against the cost of a typical delay of many months or longer for newly completed studies to clear the hurdles of a careful journal peer review.

A group of journal publishers decided during the pandemic to require preprint availability of COVID-19-related manuscripts submitted for their consideration, according to Hutchins whose own work was, as it focused on COVID-19 studies, also required to be made available as a (deeply meta) preprint.

The UWMadison researchers chose at random 100 COVID-19 studies that had been posted as preprints and then subjected to peer review and successfully published by journals. They examined how peer review affected 1,606 data points in the manuscripts, representing four types of data common to the COVID study genre: the closely-related infection fatality rates and case fatality rates, basic viral reproduction rates (how many people an infected person is expected to infect) and disease incidence (the number of new people infected in a given time period).

That was a strength of using infectious-disease research for this study, Hutchins says. Because when you talk about case fatality rate, theres an agreed-upon definition of what that is, broadly speaking, and so we could make better comparisons of that data across different labs.

Comparing preprint manuscripts to the eventual published versions of the individual studies, about 90 percent of those 1,606 data points were still in the text after peer review. More than 170 were edited out and more than 300 new data points were added across the 100-study sample.

And while the researchers found the confidence intervals associated with estimates thats like the margins of error you hear about in polling, Hutchins says had tightened about 7% after peer review, changes in the actual estimates were minor and statistically insignificant.

Wild swings between preprint and published versions would be hard to explain, Hutchins says. But thats not what we see. Theres not a whole lot of change in the data reported and the estimates based on that data.

Quantifying the differences typically seen after studies cross the peer-review finish line can help consumers of the freshest science consider how much weight they give preprint results as they report on discoveries or issue public health guidance.

Journalists and policymakers should look at the fact that 90% of the data points make it through peer review, should get a sense for how much they usually change, and ask themselves, am I comfortable accepting that degree of change? Hutchins says. The answer to that may depend based on the stakes of the decision. If all youre worried about is your reputation, you might be open to a different amount of risk than if youre making life-or-death decisions.

The National Institutes of Health has promoted preprint manuscripts as a way to accelerate the pace of scientific discovery, according to Hutchins, who developed iCite, a curated search tool for COVID-19 research, while working at NIH.

Hutchins co-authored the new study with statistician Honghan Ye, who completed his doctorate at UWMadison in 2021, and several UWMadison undergraduate students, and hopes to expand his preprint studies to include a broader range of scientific fields and how preprint quality has changed over time.

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Most preprint studies of COVID-19 hold up through peer-review - University of Wisconsin-Madison

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