Physicians treating patients with early-stage lung cancer face a conundrum: choosing potentially helpful yet toxic therapies such as chemotherapy, radiation or immunotherapy to knock out the cancer and lessen the risk of it spreading to the brain, or waiting to see if lung surgery alone proves sufficient. When up to 70% of such patients do not experience brain metastasis the spread of cancer to the brain the question arises: Who should receive additional aggressive treatments, and who can safely wait?
A new study led by Washington University School of Medicine in St. Louis could help physicians strike the right balance between proactive intervention and cautious monitoring for patients with early-stage lung cancer. The study, published March 4 in The Journal of Pathology, uses an artificial intelligence (AI) method to study patients lung biopsy images and predict whether the cancer will spread to the brain.
Subscribe to Technology Networks daily newsletter, delivering breaking science news straight to your inbox every day.
There are no predictive tools available to help physicians when treating patients with lung cancer, saidRichard J. Cote, MD, the Edward Mallinckrodt Professor and head of theDepartment of Pathology & Immunology. We have risk predictors that tell us which population is more likely to progress to more advanced stages, but we lack the ability to predict individual patient outcomes. Our study is an indication that AI methods may be able to make meaningful predictions that are specific and sensitive enough to impact patient management.
Lung cancer is the leading cause of cancer death in the U.S. and worldwide. Most lung cancers are characterized as non-small cell lung cancers, which are largely, but not exclusively, caused by smoking. For early-stage cancer patients, tumors are confined to the lung, and surgery is recommended as a first line of treatment. Roughly 30% of such patients progress to advanced stages, when the cancer spreads to the lymph nodes and other organs. With the brain often affected first, such patients require additional treatments, including chemotherapy, targeted drug therapy, radiation therapy and/or immunotherapy. However, physicians have no way of knowing whose cancer will progress, so they frequently treat patients with aggressive therapies out of caution.
Cote worked withRamaswamy Govindan, MD, the Anheuser Busch Endowed Chair in Medical Oncology and associate director of the oncology division at Washington University;Mark Watson, MD, PhD, the Margaret Gladys Smith Professor in the Department of Pathology & Immunology; and Changhuei Yang, PhD, a professor of electrical engineering, bioengineering, and medical engineering at the California Institute of Technology, to determine if AI could predict whether cancer will spread to the brain.
In diagnostic testing, a pathologist examines biopsied tissues under a microscope to identify cellular abnormalities that may hint at disease. Advanced technologies such as AI are being explored to replicate what a pathologist sees when making diagnoses but with greater accuracy, Cote explained.
A key question: Can AI detect abnormal features that a pathologist cannot?
The researchers trained a machine-learning algorithm to predict brain metastasis using 118 lung biopsy samples from early-stage non-small cell lung cancer patients. Some of the patients developed brain cancer during a five-year monitoring period, and some did not and were in remission. Then the researchers tested the AI method on its ability to predict brain metastasis, and to identify patients who develop no metastasis, using 40 other patients lung biopsy samples.
The algorithm was able to predict the eventual development of brain cancer with 87% accuracy. In comparison, four pathologists who participated in the study were an average of 57.3% accurate. Importantly, the algorithm was highly accurate in predicting which patients would not develop brain metastasis.
Our results need to be validated in a larger study, but we think there is great potential for AI to make accurate predictions and impact care decisions, said Govindan, who treats lung cancer patients atSiteman Cancer Center, based at Barnes-Jewish Hospital and Washington University School of Medicine. Systemic treatments such as chemotherapy, while effective in killing cancer cells, can also harm healthy cells and are not always the preferred treatment method for all early-stage cancer patients. Identification of patients who are likely to relapse in the brain may help us develop strategies to intercept cancer early in the process of metastasis. We think AI-based predictions could, one day, inform personalized treatments.
The AI system evaluates tumors and healthy cells features, similar to how the human brain allows us to scan facial features for quick recognition of familiar faces. However, what the algorithm sees is unknown; the scientists are working to understand the molecular and cellular features that AI uses for its predictions. This knowledge could lead to the development of novel therapeutics and influence the design of imaging instruments optimized for the collection of data for AI.
This study started as an attempt to find predictive biomarkers, said Yang. But we couldnt find any. Instead, we found that AI has the potential to make predictions about cancer progression using biopsy samples that are already being collected for diagnosis. If we can get to a prediction accuracy that will allow us to use this algorithm clinically and not have to resort to expensive biomarkers, we are talking about significant ramifications in cost-effectiveness.
Reference:Zhou H, Watson M, Bernadt CT, et al. AI guided histopathology predicts brain metastasis in lung cancer patients. J Pathol. 2024:path.6263. doi:10.1002/path.6263
This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.
See more here:
Machine Learning Predicts Lung Cancer Spread to Brain - Technology Networks
- What Is Machine Learning? | How It Works, Techniques ... [Last Updated On: September 5th, 2019] [Originally Added On: September 5th, 2019]
- Start Here with Machine Learning [Last Updated On: September 22nd, 2019] [Originally Added On: September 22nd, 2019]
- What is Machine Learning? | Emerj [Last Updated On: October 1st, 2019] [Originally Added On: October 1st, 2019]
- Microsoft Azure Machine Learning Studio [Last Updated On: October 1st, 2019] [Originally Added On: October 1st, 2019]
- Machine Learning Basics | What Is Machine Learning? | Introduction To Machine Learning | Simplilearn [Last Updated On: October 1st, 2019] [Originally Added On: October 1st, 2019]
- What is Machine Learning? A definition - Expert System [Last Updated On: October 2nd, 2019] [Originally Added On: October 2nd, 2019]
- Machine Learning | Stanford Online [Last Updated On: October 2nd, 2019] [Originally Added On: October 2nd, 2019]
- How to Learn Machine Learning, The Self-Starter Way [Last Updated On: October 17th, 2019] [Originally Added On: October 17th, 2019]
- definition - What is machine learning? - Stack Overflow [Last Updated On: November 3rd, 2019] [Originally Added On: November 3rd, 2019]
- Artificial Intelligence vs. Machine Learning vs. Deep ... [Last Updated On: November 3rd, 2019] [Originally Added On: November 3rd, 2019]
- Machine Learning in R for beginners (article) - DataCamp [Last Updated On: November 3rd, 2019] [Originally Added On: November 3rd, 2019]
- Machine Learning | Udacity [Last Updated On: November 3rd, 2019] [Originally Added On: November 3rd, 2019]
- Machine Learning Artificial Intelligence | McAfee [Last Updated On: November 3rd, 2019] [Originally Added On: November 3rd, 2019]
- Machine Learning [Last Updated On: November 3rd, 2019] [Originally Added On: November 3rd, 2019]
- AI-based ML algorithms could increase detection of undiagnosed AF - Cardiac Rhythm News [Last Updated On: November 19th, 2019] [Originally Added On: November 19th, 2019]
- The Cerebras CS-1 computes deep learning AI problems by being bigger, bigger, and bigger than any other chip - TechCrunch [Last Updated On: November 19th, 2019] [Originally Added On: November 19th, 2019]
- Can the planet really afford the exorbitant power demands of machine learning? - The Guardian [Last Updated On: November 19th, 2019] [Originally Added On: November 19th, 2019]
- New InfiniteIO Platform Reduces Latency and Accelerates Performance for Machine Learning, AI and Analytics - Business Wire [Last Updated On: November 19th, 2019] [Originally Added On: November 19th, 2019]
- How to Use Machine Learning to Drive Real Value - eWeek [Last Updated On: November 19th, 2019] [Originally Added On: November 19th, 2019]
- Machine Learning As A Service Market to Soar from End-use Industries and Push Revenues in the 2025 - Downey Magazine [Last Updated On: November 26th, 2019] [Originally Added On: November 26th, 2019]
- Rad AI Raises $4M to Automate Repetitive Tasks for Radiologists Through Machine Learning - - HIT Consultant [Last Updated On: November 26th, 2019] [Originally Added On: November 26th, 2019]
- Machine Learning Improves Performance of the Advanced Light Source - Machine Design [Last Updated On: November 26th, 2019] [Originally Added On: November 26th, 2019]
- Synthetic Data: The Diamonds of Machine Learning - TDWI [Last Updated On: November 26th, 2019] [Originally Added On: November 26th, 2019]
- The transformation of healthcare with AI and machine learning - ITProPortal [Last Updated On: November 26th, 2019] [Originally Added On: November 26th, 2019]
- Workday talks machine learning and the future of human capital management - ZDNet [Last Updated On: November 26th, 2019] [Originally Added On: November 26th, 2019]
- Machine Learning with R, Third Edition - Free Sample Chapters - Neowin [Last Updated On: November 26th, 2019] [Originally Added On: November 26th, 2019]
- Verification In The Era Of Autonomous Driving, Artificial Intelligence And Machine Learning - SemiEngineering [Last Updated On: November 26th, 2019] [Originally Added On: November 26th, 2019]
- Podcast: How artificial intelligence, machine learning can help us realize the value of all that genetic data we're collecting - Genetic Literacy... [Last Updated On: November 28th, 2019] [Originally Added On: November 28th, 2019]
- The Real Reason Your School Avoids Machine Learning - The Tech Edvocate [Last Updated On: November 28th, 2019] [Originally Added On: November 28th, 2019]
- Siri, Tell Fido To Stop Barking: What's Machine Learning, And What's The Future Of It? - 90.5 WESA [Last Updated On: November 28th, 2019] [Originally Added On: November 28th, 2019]
- Microsoft reveals how it caught mutating Monero mining malware with machine learning - The Next Web [Last Updated On: November 28th, 2019] [Originally Added On: November 28th, 2019]
- The role of machine learning in IT service management - ITProPortal [Last Updated On: November 28th, 2019] [Originally Added On: November 28th, 2019]
- Global Director of Tech Exploration Discusses Artificial Intelligence and Machine Learning at Anheuser-Busch InBev - Seton Hall University News &... [Last Updated On: November 28th, 2019] [Originally Added On: November 28th, 2019]
- The 10 Hottest AI And Machine Learning Startups Of 2019 - CRN: The Biggest Tech News For Partners And The IT Channel [Last Updated On: November 28th, 2019] [Originally Added On: November 28th, 2019]
- Startup jobs of the week: Marketing Communications Specialist, Oracle Architect, Machine Learning Scientist - BetaKit [Last Updated On: November 30th, 2019] [Originally Added On: November 30th, 2019]
- Here's why machine learning is critical to success for banks of the future - Tech Wire Asia [Last Updated On: December 2nd, 2019] [Originally Added On: December 2nd, 2019]
- 3 questions to ask before investing in machine learning for pop health - Healthcare IT News [Last Updated On: December 8th, 2019] [Originally Added On: December 8th, 2019]
- Machine Learning Answers: If Caterpillar Stock Drops 10% A Week, Whats The Chance Itll Recoup Its Losses In A Month? - Forbes [Last Updated On: December 8th, 2019] [Originally Added On: December 8th, 2019]
- Measuring Employee Engagement with A.I. and Machine Learning - Dice Insights [Last Updated On: December 8th, 2019] [Originally Added On: December 8th, 2019]
- Amazon Wants to Teach You Machine Learning Through Music? - Dice Insights [Last Updated On: December 8th, 2019] [Originally Added On: December 8th, 2019]
- Machine Learning Answers: If Nvidia Stock Drops 10% A Week, Whats The Chance Itll Recoup Its Losses In A Month? - Forbes [Last Updated On: December 8th, 2019] [Originally Added On: December 8th, 2019]
- AI and machine learning platforms will start to challenge conventional thinking - CRN.in [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- Machine Learning Answers: If Twitter Stock Drops 10% A Week, Whats The Chance Itll Recoup Its Losses In A Month? - Forbes [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- Machine Learning Answers: If Seagate Stock Drops 10% A Week, Whats The Chance Itll Recoup Its Losses In A Month? - Forbes [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- Machine Learning Answers: If BlackBerry Stock Drops 10% A Week, Whats The Chance Itll Recoup Its Losses In A Month? - Forbes [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- Amazon Releases A New Tool To Improve Machine Learning Processes - Forbes [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- Another free web course to gain machine-learning skills (thanks, Finland), NIST probes 'racist' face-recog and more - The Register [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- Kubernetes and containers are the perfect fit for machine learning - JAXenter [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- TinyML as a Service and machine learning at the edge - Ericsson [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- AI and machine learning products - Cloud AI | Google Cloud [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- Machine Learning | Blog | Microsoft Azure [Last Updated On: December 23rd, 2019] [Originally Added On: December 23rd, 2019]
- Machine Learning in 2019 Was About Balancing Privacy and Progress - ITPro Today [Last Updated On: December 25th, 2019] [Originally Added On: December 25th, 2019]
- CMSWire's Top 10 AI and Machine Learning Articles of 2019 - CMSWire [Last Updated On: December 25th, 2019] [Originally Added On: December 25th, 2019]
- Here's why digital marketing is as lucrative a career as data science and machine learning - Business Insider India [Last Updated On: January 13th, 2020] [Originally Added On: January 13th, 2020]
- Dell's Latitude 9510 shakes up corporate laptops with 5G, machine learning, and thin bezels - PCWorld [Last Updated On: January 13th, 2020] [Originally Added On: January 13th, 2020]
- Finally, a good use for AI: Machine-learning tool guesstimates how well your code will run on a CPU core - The Register [Last Updated On: January 13th, 2020] [Originally Added On: January 13th, 2020]
- Cloud as the enabler of AI's competitive advantage - Finextra [Last Updated On: January 13th, 2020] [Originally Added On: January 13th, 2020]
- Forget Machine Learning, Constraint Solvers are What the Enterprise Needs - - RTInsights [Last Updated On: January 13th, 2020] [Originally Added On: January 13th, 2020]
- Informed decisions through machine learning will keep it afloat & going - Sea News [Last Updated On: January 13th, 2020] [Originally Added On: January 13th, 2020]
- The Problem with Hiring Algorithms - Machine Learning Times - machine learning & data science news - The Predictive Analytics Times [Last Updated On: January 13th, 2020] [Originally Added On: January 13th, 2020]
- New Program Supports Machine Learning in the Chemical Sciences and Engineering - Newswise [Last Updated On: January 13th, 2020] [Originally Added On: January 13th, 2020]
- AI-System Flags the Under-Vaccinated in Israel - PrecisionVaccinations [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- New Contest: Train All The Things - Hackaday [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- AFTAs 2019: Best New Technology Introduced Over the Last 12 MonthsAI, Machine Learning and AnalyticsActiveViam - www.waterstechnology.com [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- Educate Yourself on Machine Learning at this Las Vegas Event - Small Business Trends [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- Seton Hall Announces New Courses in Text Mining and Machine Learning - Seton Hall University News & Events [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- Looking at the most significant benefits of machine learning for software testing - The Burn-In [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- Leveraging AI and Machine Learning to Advance Interoperability in Healthcare - - HIT Consultant [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- Adventures With Artificial Intelligence and Machine Learning - Toolbox [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- Five Reasons to Go to Machine Learning Week 2020 - Machine Learning Times - machine learning & data science news - The Predictive Analytics Times [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- Uncover the Possibilities of AI and Machine Learning With This Bundle - Interesting Engineering [Last Updated On: January 22nd, 2020] [Originally Added On: January 22nd, 2020]
- Learning that Targets Millennial and Generation Z - HR Exchange Network [Last Updated On: January 23rd, 2020] [Originally Added On: January 23rd, 2020]
- Red Hat Survey Shows Hybrid Cloud, AI and Machine Learning are the Focus of Enterprises - Computer Business Review [Last Updated On: January 23rd, 2020] [Originally Added On: January 23rd, 2020]
- Vectorspace AI Datasets are Now Available to Power Machine Learning (ML) and Artificial Intelligence (AI) Systems in Collaboration with Elastic -... [Last Updated On: January 23rd, 2020] [Originally Added On: January 23rd, 2020]
- What is Machine Learning? | Types of Machine Learning ... [Last Updated On: January 23rd, 2020] [Originally Added On: January 23rd, 2020]
- How Machine Learning Will Lead to Better Maps - Popular Mechanics [Last Updated On: January 30th, 2020] [Originally Added On: January 30th, 2020]
- Jenkins Creator Launches Startup To Speed Software Testing with Machine Learning -- ADTmag - ADT Magazine [Last Updated On: January 30th, 2020] [Originally Added On: January 30th, 2020]
- An Open Source Alternative to AWS SageMaker - Datanami [Last Updated On: January 30th, 2020] [Originally Added On: January 30th, 2020]
- Machine Learning Could Aid Diagnosis of Barrett's Esophagus, Avoid Invasive Testing - Medical Bag [Last Updated On: January 30th, 2020] [Originally Added On: January 30th, 2020]
- OReilly and Formulatedby Unveil the Smart Cities & Mobility Ecosystems Conference - Yahoo Finance [Last Updated On: January 30th, 2020] [Originally Added On: January 30th, 2020]