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Bousquet, J., Van Cauwenberge, P. & Khaltaev, N. Allergic rhinitis and its impact on asthma. J. Allergy Clin. Immunol. 108(5 Suppl), S147-334 (2001).

Article CAS PubMed Google Scholar

Cruz, A. A. et al. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA(2)LEN. Allergy 62(Suppl 84), 141 (2007).

Article PubMed Google Scholar

Bousquet, J. et al. Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis. Allergy 78(5), 11691203 (2023).

Article CAS PubMed Google Scholar

Custovic, A., Custovic, D., Kljaic Bukvic, B., Fontanella, S. & Haider, S. Atopic phenotypes and their implication in the atopic march. Expert Rev. Clin. Immunol. 16(9), 873881 (2020).

Article CAS PubMed Google Scholar

Barabasi, A. L., Gulbahce, N. & Loscalzo, J. Network medicine: A network-based approach to human disease. Nat. Rev. Genet. 12, 5668 (2011).

Article CAS PubMed PubMed Central Google Scholar

Ruiz, C., Zitnik, M. & Leskovec, J. Identification of disease treatment mechanisms through the multiscale interactome. Nat. Commun. 12(1), 1796 (2021).

Article ADS CAS PubMed PubMed Central Google Scholar

Pinart, M. et al. Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: A population-based cohort study. Lancet Respir. Med. 2(2), 131140 (2014).

Article CAS PubMed Google Scholar

Aguilar, D. et al. Computational analysis of multimorbidity between asthma, eczema and rhinitis. PLoS ONE 12(6), e0179125 (2017).

Article PubMed PubMed Central Google Scholar

Aguilar, D. et al. Understanding allergic multimorbidity within the non-eosinophilic interactome. PLoS ONE 14(11), e0224448 (2019).

Article CAS PubMed PubMed Central Google Scholar

Lemonnier, N. et al. A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents. Allergy 75, 32483260 (2020).

Article CAS PubMed Google Scholar

Berg, A. V. et al. GINIplus Study Group. Impact of early feeding on childhood eczema: Development after nutritional intervention compared with the natural coursethe GINIplus study up to the age of 6 years. Clin. Exp. Allergy. 40(4), 627636 (2010).

CAS PubMed Google Scholar

Guxens, M. et al. INMA Project. Cohort profile: The INMAINfancia y Medio Ambiente(Environment and Childhood) project. Int. J. Epidemiol. 41(4), 930940 (2012).

Article PubMed Google Scholar

Merid, S. K. et al. Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure. Environ. Int. 146, 106248 (2021).

Article CAS PubMed Google Scholar

Del Toro, N. et al. The IntAct database: Efficient access to fine-grained molecular interaction data. Nucleic Acids Res. 50(D1), D648D653 (2022).

Article PubMed Google Scholar

Sherman, B. T. et al. DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. https://doi.org/10.1093/nar/gkac194 (2022).

Article PubMed PubMed Central Google Scholar

Jassal, B. et al. The reactome pathway knowledgebase. Nucleic Acids Res. 48(D1), D498D503 (2020).

CAS PubMed Google Scholar

Vijaymeena, M. & Kavitha, K. A survey on similarity measures in text mining. Mach. Learn. Appl. Int. J. 3, 1928 (2016).

Google Scholar

Halkidi, M., Batistakis, Y. & Vazirgiannis, M. On clustering validation techniques. J. Intell. Inf. Syst. 2(17), 107145 (2001).

Article MATH Google Scholar

Fisher, R. A. Statistical Methods for Research Workers (Oliver & Boyd, 1970).

MATH Google Scholar

R Core Team. R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, 2001).

Google Scholar

Park, J., Lee, D. S., Christakis, N. A. & Barabsi, A. L. The impact of cellular networks on disease comorbidity. Mol. Syst. Biol. 5, 262. https://doi.org/10.1038/msb.2009.16 (2009).

Article PubMed PubMed Central Google Scholar

Zakeri, A. & Russo, M. Dual role of toll-like receptors in human and experimental asthma models. Front. Immunol. 9, 1027 (2018).

Article PubMed PubMed Central Google Scholar

Henmyr, V. et al. Characterization of genetic variation in TLR8 in relation to allergic rhinitis. Allergy 71(3), 333341 (2016).

Article CAS PubMed Google Scholar

Fuertes, E. et al. Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: Results from the TAG study. J. Allergy Clin. Immunol. 132(2), 342-352.e342 (2013).

Article CAS Google Scholar

Shalaby, K. H. et al. Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4-TRIF pathway. J. Immunol. 191(2), 922933 (2013).

Article CAS Google Scholar

Stein, M. M. et al. Innate immunity and asthma risk in Amish and Hutterite farm children. N. Engl. J. Med. 375(5), 411421 (2016).

Article CAS PubMed PubMed Central Google Scholar

Eifler, K. et al. SUMO-1 modification of IB inhibits NF-B activation. J. Cell Biol. 140, 259270 (1998).

Google Scholar

Imbert, F. & Langford, D. Viruses, SUMO, and immunity: The interplay between viruses and the host SUMOylation system. J. Neurovirol. 27(4), 531541 (2021).

Article PubMed PubMed Central Google Scholar

Liang, S. et al. Blockade of CBX4-mediated beta-catenin SUMOylation attenuates airway epithelial barrier dysfunction in asthma. Int. Immunopharmacol. 113(Pt A), 109333 (2022).

Article CAS PubMed Google Scholar

Cayrol, C. & Girard, J. P. IL-33 (IL-33): A nuclear cytokine from the IL-1 family. Immunol. Rev. 281(1), 154 (2018).

Article CAS PubMed Google Scholar

Jackson, D. J. et al. IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am. J. Respir. Crit. Care Med. 190(12), 13731382 (2014).

Article PubMed PubMed Central Google Scholar

Yang, L. et al. FGF/FGFR signaling: From lung development to respiratory diseases. Cytokine Growth Factor Rev. 62, 94104 (2021).

Article CAS PubMed Google Scholar

Yi, X. M., Lian, H. & Li, S. Signaling and functions of interleukin-33 in immune regulation and diseases. Cell Insight. 1(4), 100042 (2022).

Article PubMed PubMed Central Google Scholar

Li, J., Zhang, Y. & Zhang, L. Discovering susceptibility genes for allergic rhinitis and allergy using a genome-wide association study strategy. Curr. Opin. Allergy Clin. Immunol. 15(1), 3340 (2015).

Article CAS PubMed Google Scholar

Wise, S. K. et al. International consensus statement on allergy and rhinology: Allergic rhinitis. Int. Forum Allergy Rhinol. 8(2), 108352 (2018).

PubMed PubMed Central Google Scholar

Choi, B. Y., Han, M., Kwak, J. W. & Kim, T. H. Genetics and epigenetics in allergic rhinitis. Genes 12(12), 2004 (2021).

Article CAS PubMed PubMed Central Google Scholar

Duchesne, M., Okoye, I. & Lacy, P. Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response. Front. Immunol. 13, 975914 (2022).

Article CAS PubMed PubMed Central Google Scholar

Wagener, A. H. et al. The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression. PLoS ONE 8(11), e80257 (2013).

Article ADS PubMed PubMed Central Google Scholar

Wagener, A. H. et al. dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls. Respir. Res. 15(1), 9 (2014).

Article PubMed PubMed Central Google Scholar

Jabril-Cuenod, B. et al. Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2. J. Biol. Chem. 271(27), 1626816272 (1996).

Article CAS PubMed Google Scholar

Zhou, X. et al. A positive feedback loop reinforces the allergic immune response in human peanut allergy. J. Exp. Med. 218(7), e20201793 (2021).

Article CAS PubMed PubMed Central Google Scholar

Kannan, Y. & Wilson, M. S. TEC and MAPK kinase signalling pathways in T helper (TH) cell development, TH2 differentiation and allergic asthma. J. Clin. Cell Immunol. https://doi.org/10.4172/2155-9899.S12-011 (2012).

Article PubMed PubMed Central Google Scholar

Mor, A., Shefler, I., Salamon, P., Kloog, Y. & Mekori, Y. A. Characterization of ERK activation in human mast cells stimulated by contact with T cells. Inflammation 33(2), 119125 (2010).

Article CAS PubMed Google Scholar

Lin, W. et al. Raf kinase inhibitor protein negatively regulates FcepsilonRI-mediated mast cell activation and allergic response. Proc. Natl. Acad. Sci. USA. 115(42), E9859E9868 (2018).

Article ADS CAS PubMed PubMed Central Google Scholar

Cristinziano, L. et al. IL-33 and superantigenic activation of human lung mast cells induce the release of angiogenic and lymphangiogenic factors. Cells 10(1), 145 (2021).

Article CAS PubMed PubMed Central Google Scholar

Menche, J. et al. Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Science 347(6224), 1257601 (2015).

Article PubMed PubMed Central Google Scholar

Huttlin, E. L. et al. Architecture of the human interactome defines protein communities and disease networks. Nature 545(7655), 505509 (2017).

Article ADS CAS PubMed PubMed Central Google Scholar

Gillis, J. & Pavlidis, P. Guilt by association is the exception rather than the rule in gene networks. PLoS Comput. Biol. 8(3), e1002444 (2012).

Article ADS CAS PubMed PubMed Central Google Scholar

Schaefer, M. H., Serrano, L. & Andrade-Navarro, M. A. Correcting for the study bias associated with proteinprotein interaction measurements reveals differences between protein degree distributions from different cancer types. Front. Genet. 6, 260 (2015).

Article PubMed PubMed Central Google Scholar

Burte, E. et al. Characterization of rhinitis according to the asthma status in adults using an unsupervised approach in the EGEA study. PLoS ONE 10(8), e0136191 (2015).

Article PubMed PubMed Central Google Scholar

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