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Bitcoin's long-term outlook is brightening, according to Ark Invest's Cathie Wood.

The CEO and chief investment officer of the explosively popular active management firm told CNBC this week that the cryptocurrency's catalysts are adding up as it soars to unprecedented new highs.

"I think the probability of an ETF has gone up," Wood told CNBC's "ETF Edge" in a sweeping interview on Wednesday.

With Gary Gensler a longtime financier who taught a digital currency class at the Massachusetts Institute of Technology being nominated to lead the Securities and Exchange Commission, the watchdog could warm to crypto during the Biden administration, Wood said.

"I think we have individuals now involved who really understand the space and I think the likelihood has gone up" for a U.S.-based bitcoin ETF.

Purpose Investments gained approval for the first-ever physically backed bitcoin ETF in Canada this week. The fund began trading on Thursday.

Now that U.S. corporations including Ark Invest favorite Tesla are adding bitcoin to their balance sheets, its potential for profits has exponentially grown, Wood said.

"We expected institutional interest to pick up this year and it certainly has, but the way in which it's picked up has surprised us," she said. "I don't think we ever thought there would be broad-based substitution of bitcoin for cash on corporate balance sheets, so, we find that very interesting."

Tesla revealed a $1.5 billion bet on bitcoin through SEC filings earlier this month. Several other major players in the U.S. market including BlackRock, Mastercard and Square have also announced moves into the space.

"If all corporations in the United States were to put ...10% of their cash into bitcoin, that alone would add $200,000 to the bitcoin price," Wood said. "Now, we obviously do not believe this is going to happen very quickly. We're talking about maybe the equivalent of [a] $900 billion market cap."

Bitcoin's market value cracked $1 trillion on Friday, according to digital currency news site Coindesk.

"This has to mature a little bit before broad-based adoption can take place, but we're very reassured that companies like Square and Tesla have chosen to allocate," Wood said Wednesday.

Watch Purpose Investments founder CEO Som Seif's "ETF Edge" interview about his just-launched bitcoin ETF here.

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Ark Invest's Cathie Wood on bitcoin ETF prospects and Tesla's billion-dollar investment - CNBC